The Thermo Scientific Open Biosystems TRIPZ Lentiviral Inducible shRNAmir Library was developed in collaboration with Dr. Greg Hannon (CSHL) and Dr. Steve Elledge (Harvard). This library combines the design advantages of microRNA-adapted shRNA (shRNAmir) with the pTRIPZ lentiviral inducible vector to create a powerful RNAi trigger capable of producing RNAi in most cell types. The vector is engineered to be Tet-On and produces tightly regulated induction of shRNAmir expression in the presence of doxycycline.